Links between mutant p53 and genomic instability
نویسندگان
چکیده
منابع مشابه
NUAK1 links genomic instability and senescence
The AMP-activated protein kinase-related kinase (ARK) family comprises 13 proteins, amongst them NUAK1, that can be classified into five subfamilies: AMP-activated protein kinase (AMPK), salt-induced kinase (SIK), microtubule-affinity-regulating kinase (MARK), brain specific kinase (BRSK), and SNF1-like kinase 1 (NUAK). These proteins regulate biological responses such as metabolism, polarity, ...
متن کامل53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.
p53-binding protein 1 (53BP1) participates in the cellular response to DNA double-stranded breaks where it associates with various DNA repair/cell cycle factors including the H2AX histone variant. Mice deficient for 53BP1 (53BP1(-/-)) are sensitive to ionizing radiation and immunodeficient because of impaired Ig heavy chain class switch recombination. Here we show that, as compared with p53(-/-...
متن کامل[Mutation of p53 gene and genomic instability in testicular tumors].
BACKGROUND During the past decade, studies of human cancer have begun to yield molecular information on the identify of the multiple genetic changes in the development and progression of tumorigenesis. We investigated alterations of p53 and genomic instability in testicular tumors. MATERIALS AND METHODS Polymerase chain reaction (PCR) single-strand conformation polymorphism was performed for ...
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We hypothesize that genomic instability plays an important role in causing specific types of p53 mutations in ovarian cancer. To test this hypothesis, 78 tumors were analyzed for p53 mutations with SSCP analysis of the entire open reading frame. At the same time, alterations in 10 microsatellite loci including di-, tri-, and tetranucleotide repeats were evaluated. Fourteen (26%) of all mutation...
متن کاملp53 coordinates base excision repair to prevent genomic instability
DNA constantly undergoes chemical modification due to endogenous and exogenous mutagens. The DNA base excision repair (BER) pathway is the frontline mechanism handling the majority of these lesions, and primarily involves a DNA incision and subsequent resealing step. It is imperative that these processes are extremely well-coordinated as unrepaired DNA single strand breaks (SSBs) can be convert...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2012
ISSN: 0730-2312
DOI: 10.1002/jcb.23400